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DEPARTMENT OF CHEMISTRY Edie Banner
B.S.-University of New Orleans
(Biology) Assistant Professor Dr. Banner’s research interests fall under the broad category of natural product synthesis with a concentration on nitrogen heterocyclic compounds that exhibit bioactivity. Many of these compounds are found in amphibians and marine organisms. It has been shown that many classes of natural products share a common structural scaffold. Projects will include the development of mono- and bicyclic scaffolds that can be applied to the synthesis of a wide variety of natural products and their analogs. These synthetic endeavors will primarily be directed at targets that exhibit biological activity at sodium channels and the nicotinic acetylcholine receptor-ion channel. Collaborations will be formed to evaluate the biological activity of the compounds synthesized.
Dr. Banner and her students are also collaborating with Dr. Ricky Cox (Biochemistry) in understanding processes involved with antibiotic resistance by bacteria. In particular, her group will be synthesizing a series of chemical probes to be utilized in this collaboration to examine the ATP binding site of APH(3')-IIIa, an antibiotic modifying enzyme involved in bacterial resistance. Such studies of the active site will provide an understanding of the enzyme’s structure and mechanism which will allow for the rational design of potential inhibitors of APH(3')-IIIa in hopes of regaining the clinical effectiveness of aminoglycoside antibiotics and combating antibiotic resistance. Several classes of N-heteroaromatic compounds are being synthesized.
Selected Publications Gupton, J.T.; Banner, E.J.; Sartin, M.D.; Coppock, M.B.; Hempel, J.E.; Kharlamova, A.; Fisher, D.C.; Giglio, B.C.; Smith, K.L.; Keough, M.J.; Smith, T.M.; Kanters, R.P.F.; Dominey, R.N.; Sikorski, J. A. The Application of Vinylogous Iminium Salt Derivatives and Microwave Accelerated Vilsmeier-Haack Reactions to Efficient Relay Syntheses of the Polycitone and Storniamide Natural Products. Tetrahedron, in press, available online 15March2008. Mooberry, S.L.; Weiderhold, K.L.; Dakshanamurthy, S.; Hamel, E.; Banner, E.J.; Kharlamova*, A.; Hempel*, J.; Gupton, J.T.; Brown, M.L. Identification and Characterization of a New Tubulin-Binding Tetrasubstituted Brominated Pyrrole. Molecular Pharmacology 2007, 72, 132-140. Gupton, John T., Banner, Edith J., Scharf, Austin B.*, Norwood, Bradley K., Kanters, Rene P.F., Domminey, Raymond N., Hempel, Jonathan E.*, Kharlamova, Anastasia*, Bluhn-Chertudi, Itta*, Hickenboth, Charles R.*, Little, Barrett A.*, Sartin, Melissa D.*, Coppock, Matthew B.*, Krumpe, Keith E., Burnham, Bruce S., Holt, Herman, Du, Karen X., Keetikar, Kartik M., Diebes, Anthony, Ghassemi, Shahnaz and Sikorski, James A. “The Application of Vinylogous Iminium Salt Derivatives to an Efficient Synthesis of the Pyrrole Containing Alkaloids Rigidin and Rigidin E.” Tetrahedron (2006), 62, 8243-8255. Gupton, John T., Miller, Robert B., Krumpe, Keith E., Clough, Stuart C., Banner, Edith J., Kanters, Rene P.F., Du, Karen X., Keertikar, Kartik M., Lauerman, Nicholas E.*, Solano, John M.*, Adams, Bret R.*, Callahan, Daniel W.*, Little, Barrett A.*, Scharf, Austin B.*and Sikorski, James A. “The Application of Vinylogous Iminium Salt Derivatives to an Efficient Relay Synthesis of the Pyrrole Containing Alkaloids Polycitone A and B.” Tetrahedron (2005), 61 (7), 1845-1854. Banner, Edith J., Stevens, Edwin D., and Trudell, Mark L. “Stereoselective Synthesis of the cis-275B Decahydroquinoline Ring System.” Tetrahedron Letters (2004), 45 (22), 4411-4414.
Synthesis of Nitrogen-Heteroaromatic Compounds as Probes of APH(3')-IIIa, Andrew Johnson,* James R. Cox and Edie J. Banner, Department of Chemistry, Murray State University, Murray, KY 42071
Drew Johnson at Kentucky Academy of Science 93rd Annual Meeting
Intramolecular Cyclization of Amino Acid Derivatives for the Preparation of N-Heterocyclic Scaffolds, Jonathan Lewzader* and Edie J. Banner, Department of Chemistry, Murray State University, Murray, KY 4207
Dr. Loganathan, Dr. Banner, Jonathan Lewzader, State Rep. Melvin Henley and wife, Rita
A Combination Strategy for the Preparation of Rigidin Type Alkaloids. John T. Gupton, Edith J. Banner, Austin B. Scharf*, Barrett A. Little*, Anastasia Kharlamova*, Jonathan E. Hempel*, Melissa D. Sartin*, Matthew B. Coppock* and Brad K. Norwood, Department of Chemistry, University of Richmond, Richmond, VA 23173
A Combination Strategy for the Preparation of Storniamide and Pyrrolomycin Type Alkaloids. John T. Gupton, Edith J. Banner, John P. Ciccarelli*, Dan C. Fisher*, Brad K. Norwood, and Austin B. Scharf*, Department of Chemistry, University of Richmond, Richmond, VA 23173
Synthetic Approaches to the Rigidin Series of Alkaloids Employing Vinylogous Iminium Salts. John T. Gupton, Edith J. Banner, Stuart C. Clough, Austin B. Scharf*, Bret R. Adams*, Barrett A. Little*, Charles R. Hickenboth* and Itta Bluhn-Chertudi*, Department of Chemistry, University of Richmond, Richmond, VA 23173
PROFESSIONAL AFFILIATIONSGamma Sigma Epsilon, Member since 2004 Faculty Advisor, Zeta Epsilon Chapter, Murray State University Sigma Xi, Member since 2006 Kentucky Academy of Science, Member since 2006 American Association for the Advancement of Science, Member since 2003 Council on Undergraduate Research, Member since 2004 American Chemical Society, Member since 1999 Chair-Elect, Kentucky Lakes Section 2008
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Cox in the Department of Chemistry
Last Modified: March 21, 2008